Updated 7 November 2023 | Approved By Dr. Umberto Russo
What is Alzheimer’s disease?
Alzheimer's disease is a progressive and debilitating neurological condition that typically affects the elderly. It impairs cognitive functions such as memory, thinking, and problem-solving. The disease leads to the death of brain cells and diminishes brain health. There is currently no cure for Alzheimer's, making it a significant public health concern.Alzheimer’s disease symptoms
Alzheimer's disease is a complex condition with a range of symptoms that progress over time. These symptoms typically progress more as the disease advances. It's important to note that Alzheimer's symptoms vary from person to person, and the progression of the disease can differ as well. Common symptoms of Alzheimer's disease include [2]:- Dementia
- Memory loss
- Cognitive decline, which can affect the ability to think, problem-solve, plan, or follow instructions.
- Disorientation that can cause confusion about their time, place, or even their own identity
- Language problems include the ability to find the right words, repeat phrases, or have trouble following conversations.
- Changes in mood and behavior
- Difficulty with routine tasks (e.g., cooking, managing finances, personal hygiene, etc.)
- Misplacing items
- Poor judgment
- Social withdrawal
- Changes in personality
- Wandering
- Inability to recognize loved ones
Alzheimer’s disease causes
Alzheimer's disease is a complex condition with a variety of contributing factors, but its exact causes remain not fully understood. However, several key factors are believed to play a role. It's important to note that Alzheimer's disease is likely the result of a combination of these factors. Ongoing research aims to unravel the precise causes and mechanisms of the disease to develop better prevention and treatment strategies.- Genetic Factors: Some cases of Alzheimer's have a genetic component. Mutations in specific genes can increase the risk of developing the disease, especially in early-onset cases [3].
- Abnormal Protein Accumulation: Alzheimer's is associated with the buildup of abnormal proteins in the brain, namely beta-amyloid plaques and tau tangles [4]. These deposits disrupt brain function and cause cell damage.
- Neuroinflammation: Inflammation in the brain may contribute to the progression of Alzheimer's. The body's immune response can harm healthy brain cells [5].
- Vascular Factors: Problems with blood vessels and reduced blood flow to the brain can increase the risk of Alzheimer's. Conditions like high blood pressure and heart disease are risk factors [6].
- Environmental and Lifestyle Factors: Factors such as a lack of physical activity, an unhealthy diet, smoking [7], and excessive alcohol consumption can contribute to a higher risk of Alzheimer's.
- Age: Advanced age is the most significant risk factor. The risk of Alzheimer's increases as people get older. [8]
Alzheimer’s Disease Diagnosis and Testing
Diagnosis is a crucial step in managing Alzheimer's disease. Early detection allows for better care planning and support for individuals and their families. It's essential to consult with healthcare professionals for a proper evaluation and diagnosis. In Australia, there are also organizations and support services dedicated to helping individuals and families dealing with Alzheimer's disease [9]. It typically involves the following steps:-
- Visit to the Doctor
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- Referral to Specialists:
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- Cognitive Assessment
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- Medical Imaging
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- Blood Tests
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- Neuropsychological Evaluation
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- Spinal Fluid Analysis
Alzheimer’s disease treatment
The treatment of Alzheimer's disease focuses on managing symptoms and improving the quality of life for individuals affected. Currently, there is no cure for Alzheimer's, but various strategies and interventions are employed to address the condition [9].-
- Medications
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- Non-Pharmacological Approaches
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- Care and support
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- Lifestyle Changes and Support
Alzheimer's disease Complications
Alzheimer's disease can lead to various complications that significantly impact both individuals with the disease and their families. Some common complications include:- Behavioral and psychological changes, including aggression, agitation, and hallucinations.
- Due to safety concerns due to memory loss, the risk of wandering, and cognitive decline, those with Alzheimer's Disease are at risk of accidents and wandering.
- Stress for carers, such as family and friends
- Social isolation
- Malnutrition and dehydration
- Individuals with Alzheimer's disease may be more susceptible to infections due to weakened immune systems.
- Developing pneumonia
- Difficulty in communication
- Financial and legal challenges
 
 
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References
- Alzheimer's Association. (2023). Alzheimer's Disease Facts and Figures. https://www.alz.org/alzheimers-dementia/facts-figures
- Alzheimer's Association. (2023). Alzheimer's Disease Facts and Figures. https://www.alz.org/alzheimers-dementia/facts-figures
- National Institute on Aging. (2022). What Are the Signs of Alzheimer's Disease? https://www.nia.nih.gov/health/what-are-signs-alzheimers-disease
- Alzheimer's Association. (2023). Genetics. https://www.alz.org/alzheimers-dementia/what-is-alzheimers/causes-and-risk-factors/genetics
- Dementia Australia. (2022). Causes of Dementia. https://www.dementia.org.au/about-dementia/dementia-research/causes-of-dementia
- Leng, F., & Edison, P. (2021). Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?. Nature Reviews Neurology, 17(3), 157-172.
- Johns Hopkins Medicine. (n.d.). Vascular Dementia. https://www.hopkinsmedicine.org/health/conditions-and-diseases/dementia/vascular-dementia
- Alzheimer's Society. (n.d). Smoking and Dementia. https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/smoking-and-dementia
- Alzheimer's Association. (2023). Causes and Risk Factors. https://www.alz.org/alzheimers-dementia/what-is-alzheimers/causes-and-risk-factors
- The Royal Australian College of General Practitioners. (2016, December). Clinical Practice Guidelines and Principles of Care. Australian Family Physician, 45(12). https://www.racgp.org.au/afp/2016/december/clinical-practice-guidelines-and-principles-of-care